WebFeb 3, 2014 · GA Eye Physicians and Surgeons. Search. Home About Us; Eye Exams. New Patient Office Consultations; Routine Vision Examinations In anatomy, a crystallin is a water-soluble structural protein found in the lens and the cornea of the eye accounting for the transparency of the structure. It has also been identified in other places such as the heart, and in aggressive breast cancer tumors. Since it has been shown that lens injury may promote … See more The main function of crystallins at least in the lens of the eye is probably to increase the refractive index while not obstructing light. However, this is not their only function. It has become clear that crystallins may … See more Some crystallins are active enzymes, while others lack activity but show homology to other enzymes. The crystallins of different groups of … See more • Graw J (1997). "The crystallins: Genes, proteins and diseases". Biological Chemistry. 378 (11): 1331–1348. doi:10.1515/bchm.1997.378.11.1299. PMID 9426193 See more Crystallins from a vertebrate eye lens are classified into three main types: alpha, beta and gamma crystallins. These distinctions are based on the order in which they elute from a gel filtration chromatography column. These are also called ubiquitous … See more • Crystallins at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • alpha-Crystallins at the U.S. National Library of Medicine Medical Subject Headings See more
Requirement for the c-Maf transcription factor in crystallin gene ...
WebFeb 4, 1997 · Three classes of crystallins are present in vertebrate lenses: α, β, and γ. α-Crystallins compose up to 50% of the total protein mass of the mammalian lens and are isolated under physiologic conditions as a high-molecular mass aggregate of ≈800,000 Da ().There are two different α-crystallin polypeptides, αA-crystallin (αA) and αB-crystallin … WebIntroduction. Bietti crystalline dystrophy ((BCD), Online Mendelian Inheritance in Man (OMIM) OMIM210370) is an inherited autosomal recessive disease linked to biallelic … greenhousesensation.co.uk
UniProt
WebDescription: Homo sapiens crystallin, beta B2 (CRYBB2), mRNA. ... This gene, a beta basic group member, is part of a gene cluster with beta-A4, beta-B1, and beta-B3. A chain-terminating mutation was found to cause type 2 cerulean cataracts. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) WebThe importance of alpha-crystallins in the maintenance of lens transparency was demonstrated by the work of Brady et al. (1997), who showed that mice homozygous for a targeted disruption of the alpha-A-crystallin gene developed cataracts and had cytoplasmic inclusion bodies containing the small heat-shock protein alpha-B-crystallin (123590). WebAug 1, 2024 · The founding β/γ-crystallin gene arose from the ancestral Hspb1-like gene promoter inserted into a Ca2+-binding protein coding region, early in the cephalochordate/tunicate lineage. Likewise, an ancestral aldehyde dehydrogenase (Aldh) gene, through multiple gene duplications, expanded into a multigene family, with specific … greenhouse sensation thermoset