Glut2 translocation
WebJul 26, 2024 · Interestingly, GLUT2 activity is modulated by its cellular localization. Membrane translocation specifically regulates GLUT2 activity in enterocytes, pancreatic β-cells, hepatocytes, and proximal ... WebAug 1, 2001 · Insulin resistance represents a major pathogenic impairment in the development of type 2 diabetes (1,2).In humans and rodents, skeletal muscle is the primary site of insulin-mediated glucose disposal ().Insulin increases glucose uptake in muscle by eliciting GLUT4 translocation from an intracellular storage site to both the plasma …
Glut2 translocation
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WebFeb 13, 2015 · Confocal microscopy revealed that the distribution of SGLT1 and GLUT2 transporters in absorptive cells of the intestinal villus was altered depending on maltose concentration. ... Y. and Sarr, M.G., Translocation of transfected GLUT2 to the apical membrane in rat intestinal IEC-6 cells, Dig. Dis. Sci., 2012, vol. 57, pp. 1203–1212. … WebDec 28, 2024 · The effects of berberine on intestinal glucose transport and GLUT2 …
WebRegulated GLUT2 translocation was first described at the apical membrane of rat enterocytes (33), and the physiological relevance of this process was rapidly established (18). Indeed, glucose ... WebGLUT2 (SLC2A2) is expressed in the intestine and kidney where it plays an important …
WebNov 25, 2011 · Aim In this study, we transfected the full length cDNA of glucose transporter 2 (GLUT2) into IEC-6 cells (which lack GLUT2 expression) to investigate GLUT2 translocation in enterocytes. The purpose of this study was to investigate cellular mechanisms of GLUT2 translocation and its signaling pathway. Methods Rat GLUT2 … WebFeb 26, 2014 · The fact that the methods applied play a critical role in the ability to prove translocation of GLUT2– even in rats – becomes evident as for example in one study the presence of apical GLUT2 was demonstrated in perfused, isolated intestinal segments whereas the same group failed to show this in everted intestinal sleeves .
WebJun 26, 2024 · It is well established that GLUT2, the main regulator of hepatic hexose flux, and GLUT4, the workhorse in insulin- and contraction-stimulated glucose uptake in skeletal muscle, are critical contributors in the control of whole-body glycemia. ... mainly facilitated by an acute translocation of GLUT4 transporter vesicles to the plasma membrane ...
WebThe analysis of GLUT2, from genotype to phenotype, may help uncover other … africom mottoWebopening of the translocation pore, which helps to determine which hexoses can be transported. If substantiated, the elucidation of this mechanism may prove useful in the design of hexose analogs for use in cancer imaging and therapeutics. glucose transporter proteins; SLC2A7; intestinal hexose absorption; structure-function Cloning linux vi できないWebThere are several possibilities for GLUT2 translocation from the BLM to the BBM of the KPTCs: First, translocation supports active transport by SGLT2 that cannot withstand the overload of glucose (a compensatory-deteriorative effect) [49,57]. Second, GLUT2 is recruited to the apical side to act as a glucose sensor (as suggested in other organs). africom visionWebOct 1, 2005 · Inhibition of apical GLUT2 insertion parallels inhibition of GLUT4 translocation by glucocorticoid in muscle . The first indication of this mechanism was obtained in opportunistic studies from a real-life situation, as a stress response in rats was caused by noise and vibration from renovation and construction during expansion of the … afri competitive grantWebNov 25, 2011 · In this study, we transfected the full length cDNA of glucose transporter 2 … linux weston カスタマイズWebGLUT2: Is a bidirectional transporter, allowing glucose to flow in 2 directions. Is … africom vaccineWebFeb 13, 2015 · Translocation of GLUT2 from cytoplasmic vesicles into the apical membrane markedly increases the capacity of glucose uptake by the enterocyte[19][20] [21]. Thus, any factor that influences the ... linux vim 検索 ハイライト