Platinum-containing doublet chemotherapy

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August undefined, 2024

WebbIn IMpower110 (NCT02409342), 1L atezo (anti–PD-L1) improved OS vs platinum-doublet chemo (PDC) in pts with PD-L1–high NSCLC and ECOG PS ≤1. However, ≥40% of NSCLC pts have poor ECOG PS (≥2) and/or substantial comorbidities, resulting in ineligibility for platinum-based chemo and most 1L clinical trials. IPSOS is a global, multicenter, open … WebbWikipedia

Platinum doublets as first-line treatment for elderly patients with ...

WebbAlthough first-line platinum-containing chemotherapy results in objective responses or stable disease in approximately 65–75% of patients, ... first-line systemic therapy for patients with locally advanced or metastatic UC has consisted of platinum-doublet chemotherapy. Beyond chemotherapy, several antiangiogenic agents (bevacizumab ... Webbplatinum-based doublet chemotherapy) and progressed are eligible. However, subjects who received a tyrosine kinase inhibitor after failure of a prior platinum-based therapy … exegese dick tome 1 pdf

FDA approves neoadjuvant nivolumab and platinum-doublet …

WebbThe most common adverse reactions in ≥20% of patients receiving nivolumab in combination with ipilimumab and platinum-doublet chemotherapy were fatigue, musculoskeletal pain, nausea, diarrhea ... Webbför 2 dagar sedan · The type of platinum-containing doublet chemotherapy was selected by investigators according to treatment practices of therapeutic institutions—paclitaxel in combination with cisplatin was given to patients with squamous NSCLC, while pemetrexed in combination with cisplatin was given to patients with non-squamous NSCLC. Webb3 juni 2024 · Platinum-containing doublet chemotherapy is generally regarded as the standard first-line treatment for patients with RMNPC. The randomized phase III trial of gemcitabine and cisplatin (GC) versus 5-fluorouracil and cisplatin (PF) in RMNPC established GC as the standard of care first-line regimen. exegese fatiha

OA07.04 Overall Survival in Patients with Advanced

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WebbThe platinum-based drugs cisplatin, carboplatin and oxaliplatin are regularly prescribed in the treatment of cancer and while they are effective, their use is limited by their severe, dose-limiting side effects (also referred to as adverse effects/events). In total, a cancer patient can experience any combination of around 40 specific side effects. Webb15 apr. 2016 · Dr. Jack West, Swedish Cancer Institute, identifies the platinum-based chemotherapy doublet as the backbone of first-line treatment for the majority of NSCLC … exeger historyWebb1 apr. 2024 · platinum-containing doublet chemotherapy. 9. In the pri-mary analysis, reported after a median follow-up of 18.3. months, median OS in the PD-L1 ... bt4 torrent

"Webb7 mars 2016 · This non-platinum–containing chemotherapy regimen including bevacizumab met the study-specified definition of effectiveness and improved symptoms of lung cancers. The toxicities were comparable to those in phase II experiences with platinum doublet regimens plus bevacizumab. " - Platinum-containing doublet chemotherapy

Platinum-containing doublet chemotherapy

Docetaxel plus cetuximab biweekly is an active regimen for the …

Webb30 maj 2024 · Platinum-doublet chemotherapy has been conventionally used for patients with advanced gastroenteropancreatic (GEP) neuroendocrine carcinoma (NEC) but … WebbPlatinum‑containing doublet chemotherapy is the cornerstone of lung cancer treatment; however, cisplatin resistance is a major obstacle in the treatment of lung cancer. …

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WebbPurpose: To assess the efficacy of pemetrexed plus platinum doublet chemotherapy as first-line treatment for advanced nonsquamous non-small-cell lung cancer (NSCLC) through a trial-level meta-analysis. Methods: Trials published between 1990 and 2015 were identified by an electronic search of public databases (Medline, Embase, and Cochrane … WebbPlatinum-based chemotherapy remains the standard-of-care for most patients affected by advanced non-small cell lung cancer (NSCLC). The platinum compounds currently used …

Webb2 nov. 2024 · Platinum-based chemotherapy drugs are used to treat many types of cancer, including lung, breast, ovarian, and testicular cancer. … Webb332P - A phase II, open-label, single-center study of QL1706 plus platinum doublet chemotherapy with bevacizumab as first-line treatment in patients with advanced NSCLC: Data from ... a novel dual immune checkpoint blockade containing a mixture of anti-PD1 IgG4 and anti-CTLA4 IgG1 antibodies, showed promising antitumor efficacy in advanced ...

Webb11 okt. 2010 · A Randomized, Double-Blind, Placebo-Controlled, Study of the Safety and Efficacy of Farletuzumab in Combination With a Platinum-Containing Doublet in Chemotherapy-Naive Subjects With Stage IV Adenocarcinoma of the Lung (FLAIR) Actual Study Start Date : June 27, 2011: Actual Primary Completion Date : Webb29 maj 2014 · Reactive platinum molecules bind to nucleophilic groups containing oxygen, nitrogen, or sulfur donors . These groups are omnipresent in a cell, ... BMS-936558, ONO-4538) plus platinum-based doublet chemotherapy (PT-doublet) in chemotherapy-naive non-small cell lung cancer (NSCLC) patients (pts).

Webbför 2 dagar sedan · The type of platinum-containing doublet chemotherapy was selected by investigators according to treatment practices of therapeutic institutions-paclitaxel in combination with cisplatin was given...

bt4z14450aa battery terminalsWebb13 apr. 2024 · Triple-negative breast cancer (TNBC) is the most aggressive and lethal breast cancer (BC) subtype. 1 Chemotherapy still represents the backbone of the first-line treatment for patients with advanced TNBC (aTNBC). In patients with programmed death-ligand 1 (PD-L1)-negative aTNBC, single-agent or combination chemotherapy represents … bt4 wifi密码Webb19 juni 2024 · A Study of Atezolizumab Compared With a Single-Agent Chemotherapy in Treatment Naïve Participants With Locally Advanced or Recurrent or Metastatic Non-Small Cell Lung Cancer Who Are Deemed Unsuitable For Platinum-Doublet Chemotherapy - Full Text View - ClinicalTrials.gov Home Search Results Study Record Detail Save this study exegese ibn kathirWebbImmunotherapy plus platinum doublet chemotherapy (chemo) as first-line therapy has shown survival benefit in patients (pts) with advanced NSCLC not harboring oncogenic … exegeses companion bibleWebbplatinum-containing chemotherapy on the same day Use separate infusion bags and filters for each infusion Do not coadminister other drugs through the same IV line Flush the entire IV line at the end of infusion YERVOY Do not shake product Inspect parenteral drug products visually for particulate matter and discoloration prior to administration. bt 4k youview boxWebb11 apr. 2024 · The type of platinum-containing doublet chemotherapy was selected by investigators according to treatment practices of therapeutic institutions—paclitaxel in combination with cisplatin was given ... exegese david und goliathThis protocol of the systematic review and network meta-analysis has been uploaded on the website of International Prospective Register of Systematic Reviews (42016052455)10. We … Visa mer Search formulas for electronic databases were created with the support of Cochrane Japanese. Search formulas for MEDLINE, EMBASE, the Web of Science Core Collection, and the Cochrane Central Register of Controlled … Visa mer The primary outcome was hazard ratio (HR) for overall survival (OS, HROS)16. The co-secondary outcomes were HR for progression-free survival (FPS, HRPFS)16, odds ratio (OR) for … Visa mer We assessed the quality of original studies using six domains of the Cochrane Risk of Bias evaluation sheet: selection, performance, detection, attrition, reporting, and other biases4. Visa mer exegese traduction