Webb28 juni 2024 · Cancer therapy has evolved beyond solely targeting cancer cells and now considers the tumor microenvironment (TME) as well. The cellular and acellular … Webb1 juli 2024 · SLC7A11 is a cystine transporter that has been identified as a potential therapeutic target in PDAC cells. However, no prior study has evaluated the role of SLC7A11 in PDAC tumor stroma and its prognostic significance.

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WebbSLC7A11为溶质载体家族成员之一，该基因编码胱氨酸/谷氨酸反转运体Xc-系统的轻链亚基 SLC7A11 (又称 xCT)。 通过介导胱氨酸摄取和谷氨酸释放促进谷胱甘肽的合成，保护细胞免受氧化应激，维持细胞的氧化还原平衡，阻止脂质过氧化诱导的细胞死亡。 SLC7A11在多种恶性肿瘤中过表达，与乳腺癌、卵巢癌、肝癌和肺癌等恶性肿瘤的生长、预后、转移和 … Webb而近期的研究证实，SLC7A11主要通过抑制铁死亡来促进放射抗性。. 有趣的是，最新的研究表明SLC7A11介导的谷氨酸输出可与肿瘤免疫系统相互作用并调节肿瘤免疫系统，进而影响肿瘤的生长和对癌症疗法的反应。. 综上所述， SLC7A11在肿瘤生物学中铁死亡非依赖性 … sharing caring vhs

一箭双雕！胰腺癌新靶点SLC7A11：突破胰腺癌防御堡垒“潜力军”

Webb22 juni 2024 · Accumulating evidence has shown that the expression of SLC7A11 is fine-tuned at multiple levels, and plays diverse functional and pharmacological roles in … WebbOne emerging hypothesis posits that glioma glutamate release is a consequence of enhanced self-preservation by tumor cells. Through an up-regulation of a … Webb18 apr. 2024 · Indeed, overexpression of xCT has been reported in nonsmall cell lung cancer, breast cancer, and liver cancer and is associated with poor outcomes (18–21). Furthermore, xCT has been implicated in promoting tumorigenesis through its antioxidant function, which supports breast cancer cell proliferation ( 19 ), matrix invasion of glioma … poppy icelandic red